Dicloran Gel Mechanism of Action

Pharmacology: Pharmacodynamics: Dicloran gel is an anti-inflammatory and analgesic preparation designed for external application. It contains a quantity of active substance equivalent to 1% Diclofenac Sodium. Dicloran gel can be easily rubbed into the skin due to its unique gel base.
Dicloran gel has major anti-inflammatory properties, which apparently are related to the inhibition of cyclo-oxygenase, a decrease in prostaglandin synthesis, and an increase in the reuptake of arachidonic acid into cellular pools.
Dicloran gel is suitable for use in inflammatory and degenerative rheumatic disease, as well as for the treatment of post-traumatic inflammation and swelling.
Pharmacokinetics: Clinical Pharmacology: Diclofenac is a Nonsteroidal anti-inflammatory drug (NSAID). In Pharmacologic studies, Diclofenac has shown anti-inflammatory, antipyretic and analgesic activity. As with the other NSAIDs, the mode of action is not known. Its ability to inhibit prostaglandin synthesis, may however be involved in its anti-inflammatory activity, as well as contribute to its efficacy in relieving pain related to inflammation and primary dysmenorrhea. With regards to its analgesic effect, diclofenac is not a narcotic.